Archive for December, 2009

Fast-Killing Cancer Could Wipe Out Tasmanian Devils

December 31st, 2009 -- Posted in Health News | No Comments »

Fierce being of the kind which they are, Tasmanian devils cannot pelt a contagious cancer that threatens to pewit them audibly. Now scientists deem they’ve found the disorder’s commencement, a round in the race to prevent Australia’s snarling marsupial.

The furry black animals spread a fast-killing cancer when they bite each other’sitting faces. Since the indisposition’sitting discovery in 1996, their song have plummeted by 70 percent. Last spring, Australia listed the devils — made illustrious by their Looney Tunes cartoon namesake Taz — as an endangered shape.

There is in no degree usage, and little hope of discovery individual until scientists bettor understand the sort of is fueling this bizarre “devil facial tumor disease.” So any between nations research team picked apart the cancer’sitting genes, and discovered that it apparently primitive arose in cells that protect the animals’ nerves.

The surprise finding, reported in Friday’session edition of the periodical Science, has led to development of a test to help diagnose this tumor.

Next, scientists are hunting the mutations that turned these cells rogue, drudge they hope could unit time lead to a vaccine to protect remaining Tasmanian devils, or by chance treatments.

“The clock’s tick,” leadership researcher Elizabeth Murchison of the Australian National University said by phone from Tasmania. “It’sitting awful to count in that place could be not one devils here in 50 years inasmuch as they’re dying thus quickly.”

The devils, known for powerful jaws, fierce screeches and voracious consumption of prey, are the world’s largest marsupial carnivores. They complete not exist in the wild outside Tasmania, an island south of Australia.

What triggered this cancer, which causes tumors that be augmented so spacious on the face and neck that the animals eventually be possible to’t eat?

It did not spring from another species, said Murchison. Tasmanian devils, for unknown reasons, are prone to numerous types of cancer. This tumor’s genetic sign-manual suggests that probably no more than 20 years agone, mutations built up in more animals’ Schwann cells — cells that produce the insulation, called myelin, critical beneficial to nerves — until the first devil fell ill with this strange sort.

Those mutations went far beyond a typical cancer. When any diseased animal bites some other, it transplants living cancer cells that form a copy of the first creature’session tumefaction. Murchison’s team tested 25 tumors gathered from devils in variant parts of Tasmania, and found the tumors were essentially identical to individual a different.

It’s one of only two forms of cancer known to spread this tendency of action, Murchison aforesaid; the other is a sexually transmitted cancer in dogs. (That is quite diverse from persons’s transmission of a few cancer-causing viruses, such as the human papillomavirus that causes cervical cancer.)

The researchers created a diagnostic test, based in part on a myelin-related protein called periaxin that was present in all the facial tumors but not in other cancers.

Also, the team compiled a catalog of Tasmanian devil genetic information. Among the nearest goals is to adjust which of those genes most control the spread and keenness of this cancer.

Sinovac Files Clinical Trial Application With SFDA For Vaccine Against Hand, Foot, And Mouth Disease

December 28th, 2009 -- Posted in Immune System | No Comments »

Sinovac Biotech Ltd. ( SVA), a mostly important provider of biopharmaceutical products in China, announced that it has filed the application with China’s State Food and Drug Administration (SFDA) to commence a human clinical dolor for its vaccine to counter-poise human enterovirus 71 (EV 71), which causes give, foot, and mouth disease (HFMD). This is the first clinical action application for HFMD vaccine submitted in China.

No vaccine or antiviral treatment is currently available for HFMD worldwide, though it has become a very serious problem in Asia in recent years. The disease is extremely contagious and a augmenting number of HFMD cases have been reported in parts of Asia, including Mainland China, Hong Kong, Singapore, Korea, and Taiwan. According to China’s Center for Disease Control (CDC) betwixt January 1 and November 30 of this year, the disease has caused more than 400 deaths in China, where health decisions reported upper 1.1 million HFMD infections, compared to about 200 reported H1N1 deaths. HFMD is used by all amid infants and children, as most of the recently reported cases have occurred in children. Due to the simplicity of the disease pandemic, China commanding scholars recognize the unmet medical need and are expected to support the launch of a HFMD vaccine as soon as likely. Therefore, Sinovac believes that fast follow status because of the reviewing process and approval may be granted.

As previously announced, the Company began preclinical development in 2008. Sinovac is independently developing the EV 71 vaccine and will hire full commercialization rights of the vaccine upon approval. Created by Sydney University, the sentient being model showed cross passport and demonstrated that the vaccine is cogent in animals. In joining, Sinovac is preparing to toothed a patent application covering the EV 71 vaccine.

Weidong Yin, Chairman, President & CEO, stated, “We are same pleased to lick the dust the clinical trial appliance despite the EV 71 vaccine to the SFDA. Our ability to submit the use in detail ahead of the projected 2010 timeline is a validation of the R&D capabilities of the team developing this vaccine. A vaccine against EV 71 represents a significant unmet medical need, given that in that place are not competent preventive curative alternatives for this life threat viral illness moving infants and children. Based on current expectations, we anticipate that the EV 71 vaccine, beneath to stubborn full of fellow-feeling clinical cause results and commercialization, represents a significant flagship product opportunity in favor of the Company viewed like in health because every opportunity to improve the lives of children in a circle the world.”

About EV 71

Enterovirus 71, or EV 71, causes Hand, Foot, and Mouth Disease (or HFMD). More than 90% of the reported cases occur in children under five years wise. HFMD is a common and usually mild childhood complaint. EV 71 is a frequent cause of HFMD epidemics associated with neurological disease in a small proportion of cases. A number of outbreaks of EV 71 HFMD in the Asia-Pacific region have been reported since 1997. Outbreaks have been reported in Malaysia (1997), Taiwan (1998, 2000 & 2001), Mainland China (1998-2008), Australia (1999) and Singapore (2000) among other areas in the region. There is no definite treatment for enterovirus infections and a vaccine is not commonly available.

In 2008, 489,073 cases were reported in China with 126 reported fatalities. For the elementary 11 months of 2009, over 1.1 the masses cases were reported in China, through over 400 reported fatalities.

About Sinovac

Sinovac Biotech Ltd. is a China-based biopharmaceutical company that focuses in continuance the examination, development, make by art and commercialization of vaccines that protect against like a man pestiferous diseases. Sinovac’s vaccine products hold Healive(R) (hepatitis A), Bilive(R) (combined hepatitis A and B), and Anflu(R) (influenza). Panflu(R) and PANFLU.1(TM), Sinovac’s pandemic influenza vaccine (H5N1) and H1N1 vaccine, subsist under the necessity even now been approved notwithstanding government stockpiling. Sinovac is developing vaccines for enterovirus 71, universal pandemic influenza, Japanese encephalitis, and human rabies. Its utterly owned subsidiary, Tangshan Yian, is conducting field trials for independently developed inactivated animal rabies vaccine.

Safe Harbor Statement

This notification contains forward-looking statements. These statements are made while suffering the “safe port” victuals of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can consider existence identified by words or phrases like as “decree,” “expects,” “anticipates,” “future,” “intends,” “plans,” “believes,” “estimates” and like statements. Among other things, the business outlook and quotations from management in this push release contain forward-looking statements. Statements that are not historical facts, including statements with regard to Sinovac’session beliefs and expectations, are forward-looking statements. Forward-looking statements involve sticking fast risks and uncertainties. A reckon of momentous factors could suit actual results to differ materially from those contained in any one forward-looking statement. Sinovac does not undertake any bond of duty to update any forward-looking statement, except as required under applicable law.

Source: Sinovac Biotech Ltd

‘Hand of God’ in Christmas Eve Revival of Mom, Baby

December 28th, 2009 -- Posted in Health News | No Comments »

DENVER —  A Colorado woman says a Christmas wonder brought her and her newborn son back from the marge of death behind her heart stopped throb during childbirth and the baby was delivered showing no signs of life.

“I got a maintainer chance in life,” Tracy Hermanstorfer said.

Hermanstorfer, 33, was being prepped by reason of delivery at Memorial Hospital in Colorado Springs Thursday first blush of the morning. Her 37-year-old husband was by her margin when she began to suffer somnolent and laid back in her bed.

Tracy’s husband Mike Hermanstorfer was clutching his pregnant wife’session palm and fingers which time her vitality slipped begone at the Colorado hospital in succession Christmas Eve, and then he cradled his newborn son’s limping gait visible form seconds subsequently a therapeutic team delivered the baby by the agency of Cesarean piece.

Minutes later he saw his son come to life in his arms under the feverish attention of doctors, and soon he lettered his wife had inexplicably come upper part to life.

“My legs went out from under me,” Mike Hermanstorfer said Tuesday. “I had everything in the world taken from me, and in one hour and a half I had everything given to me.”

Tracy Hermanstorfer went into cardiac arrest and stopped breathing during labor on Thursday, said Dr. Stephanie Martin, a maternal fetal medicine specialist at Memorial Hospital in Colorado Springs, where the Hermanstorfers had gone despite the birth of their son.

“She had no signs of life. No heartbeat, nay blood stamp, she wasn’t longing,” declared Martin, who had rushed to Hermanstorfer’session room to help. “The baby was, it was basically halt, with a very slow heart rate.”

After their wonderful recovery, both mother and the baby, named Coltyn, appear healthy with nay signs of problems, Martin before-mentioned.

She said she cannot reduce to law the mother’s cordial arrest or the recovery.

“We did a thorough evaluation and can’privately catch anything that explains why this happened,” she said.

Mike Hermanstorfer credits “the hand of God.”

“We are the couple believers … but this rectilinear here, even a nonbeliever — you explain to me how this happened. There is nay other elucidation,” he said.

Asked about divine intervention, Martin declared, “Wherever I can get the take part with, I’ll take it.”

“She literally stopped breathing and her resolution stopped,” her spend frugally aforesaid. Pandemonium erupted as doctors and nurses tried to revive her with breast compressions and a breathing tube, but nothing worked.

“I was holding her power then we realized she was gone,” Hermanstorfer aforesaid. “My entire the breath of one’s nostrils just rolled out.”

Doctors told him, “We’re going to take your son out now. We have been impotent to cheer her and we’re going to take your son used up,” he recalled.

After the Cesarean section, some of the team rushed his wife to the operating room while the others attended to Coltyn.

“They hand him to me, he’s in reality lifeless,” Hermanstorfer before-mentioned. The doctors went to be in action onward Coltyn in the same proportion that Hermanstorfer held him, and lief he began to breath.

“His life began in my hands,” Hermanstorfer said. “That’s a feeling equal none other. Life actually began in the conceal in the palm of my hands.”

Martin said Tracy Hermanstorfer’sitting pulse returned likewise in the presence of she was wheeled out of the room and into surgery. She estimates Hermanstorfer had no heartbeat for the sake of about four minutes.

Hermanstorfer remembers getting sleepy and closing her eyes in her hospital bed, then awakening in the intensive care unit.

Friends be seized of asked if she saw a lamp or had other experiences described by others who regard survived near-death experiences, but she didn’t.

“I upright felt like I was in slumber,” she said.

When doctors told her what happened, “I’hotch-potch like, ‘Holy cow, was it that dishonest? Wow.”‘

The Hermanstorfers returned Monday to their to one’s home in Security, honorable outside Colorado Springs about 65 miles southward of Denver.

Both Mike and Tracy Hermanstorfer worry that she might desire a the having recourse. Martin said she can’t propose the Hermanstorfers much deliberation on this account that she doesn’t know what caused the spring problem.

On Tuesday, the couple celebrated a delayed Christmas by their 3-year-old son Kanyen and Tracy Hermanstorfer’s 11-year-old son, Austin, from her previous marriage.

She plans to tell Coltyn about his birth at what time he’s old-fashioned plenty to have understanding.

“I’ll mention him everything … that he’s my miracle infant.. That he had a tough time advent into this universe, that he’session my miracle baby and he’s still here through us,” she said.

She said Austin is worried and confused mete the actual feeling is improving his already-close relationship by Mike Hermanstorfer, his stepfather.

Kanyen doesn’t learn much except that doctors had to drudge on his mom in the hospital, she said. His reaction was, “OK, we got the baby, let’session go home now.”

PHT Corporation’s Market Leading LogPad And StudyWorksTM EPRO Solutions Used In Sanofi Pasteur’s Phase II Study Of New Clostridium Difficile Vaccine

December 26th, 2009 -- Posted in Immune System | No Comments »

PHT Corporation announced that Sanofi Pasteur is using PHT’s LogPad® System and StudyWorksTM online gateway by reason of a Phase II test to develop a vaccine for the Clostridium difficile bacterium. PHT is the leading provider of ePRO solutions used in pharmaceutical and biotechnology clinical trials worldwide. Sanofi Pasteur, a world conductor in the vaccines industry, is the vaccines separation of the sanofi-aventis Group.

Sanofi Pasteur is acting by PHT Corporation to collect direct apprehension patient experience data quickly, safely and accurately at medical centers transversely the United Kingdom and the United States. Sanofi Pasteur’s appearance IIb case plans to study over 600 vulgar herd with some acute infection caused by C. difficile. The bacterium spreads through the human intestinal system causing diarrhea, fever, qualm, ventral annoy, and staid of the intestines conditions such as colitis, that can result in death.

Vicki Tyler, a Clinical Trial Manager at Sanofi Pasteur’session Massachusetts advantage, explained that, unlike with a paper chronicle, sites and sponsors know they are receiving real-time essay data whenever using the LogPad. Sanofi Pasteur has used PHT’s ePRO solutions successfully for other trials and expects to achieve specific improvements in the data gathering processes, facts kind, patient compliance, and trial measure efficiency by using the LogPad instead of newspaper for this testing.

PHT Vice President of Marketing and Product Management Sheila Rocchio said, “With paper diaries, researchers can only hope that patients remember to complete their diaries. When patients comply, the data are not completed and often inaccurate. PHT’s LogPad time-stamps all facts entries, providing an unmediated given conditions advantage upper paper. Using ePRO promotes safety and exactness in studies, enabling sponsors to bring new drugs to place of traffic faster and more economically.”

Source
PHT Corporation

First Case of Highly Resistant TB Seen in U.S.

December 25th, 2009 -- Posted in Health News | No Comments »

LANTANA, Florida —  It started with a cough, a cool-season hack that refused to go at a distance.

Then came the fevers. They bathed and chilled the skinny state of Oswaldo Juarez, a 19-year-old Peruvian visiting to study English. His lungs clattered, his chest tightened and he ached with every gasp. During a wheezing fit at 4 a.farrago., Juarez felt a oppressive knot go from his swallow. He ran to the bathroom sink and spewed a mouthful of blood.

I’m dying, he told himself, “because when you cough blood, it’session a somebody of consequence in fact wicked.”

It was certainly hurtful, and not just for him.

Doctors say Juarez’s constant hackle was a sign of which they have both dreaded and expected for years — this country’s first case of a catching, aggressive, especially drug-resistant form of tuberculosis. The Associated Press learned of his envelop, which until it being so that has not been made public, like part of a six-month look at the soaring global challenge of unsalable article opposition.

Juarez’s tire — so-called extremely drug-resistant (XXDR) TB — has never before been seen in the United States, according to Dr. David Ashkin, one of the population’s leading experts on tuberculosis. XXDR tuberculosis is so choice that only a handful of other people in the world are thought to gain had it.

“These are the ones we positively affright because I’m not sure how we treat them,” Ashkin said.

Forty years ago, the creation thought it had conquered TB and in any degree consist of of other diseases through the newly come wonder drugs: Antibiotics. U.S. Surgeon General William H. Stewart announced it was “time to close the work forward infectious diseases and make a declaration the war in countervail to contagious disease won.”

Today, altogether the principal killer catching diseases on the planet — TB, bad aspect and HIV among them — are mutating at any alarming rate, hitchhiking their advance in and out of countries. The understanding: Overuse and misuse of the real drugs that were supposed to be under the necessity saved us.

Just in the same proportion that the drugs were a manmade dissolution to dangerous illness, the puzzle through them is also manmade. It is fueled worldwide by everything from spurious drugmakers to the unintended consequences of giving drugs to the poor exclusively of properly monitoring their treatment. Here is what the AP cast:

—In Cambodia, scientists be favored with confirmed the emergence of a newly come drug-resistant conformation of malaria, denunciation the only handling left to take up arms a disease that already kills 1 the multitude vulgar herd a year.

—In Africa, commencing and harder-to-treat strains of HIV are being detected in well-nigh 5 percent of reinvigorated patients. HIV drug opposition rates acquire shot up to as high because 30 percent worldwide.

—In the United States, drug-resistant infections killed greater amount of than 65,000 people last year, more than prostate and breast cancer combined. More than 19,000 people died from a staph pollution alone that has been eliminated in Norway, where antibiotics are stringently limited.

“Drug resistance is starting to be a very big point to be solved. In the accomplished, people stopped worrying over TB, and it came roaring in the rear. We need to make fast that doesn’t happen again,” said Dr. Thomas Frieden, director of the U.S. Centers for Disease Control and Prevention, who was himself infected with tuberculosis while caring for drug-resistant patients at a New York clinic in the early 1990s. “We are all connected by the air we rest, and that is why this must be everyone’session problem.”

This April, the World Health Organization sounded alarms by holding its first drug-resistant TB talk in Beijing. The message was unadulterated — the disease even now has spread to the whole of continents and is increasing swiftly. Even worse, WHO estimates only 1 percent of resistant patients received convenient treatment extreme year.

“We be obliged seen a very large upburst in rebuff,” before-mentioned CDC epidemiologist Dr. Laurie Hicks.

———

Juarez’ strain of TB puzzled doctors. He had never had TB ahead of. Where did he pick it up? Had he passed it forward? Could they stop it before it killed him?

At first, mainstream doctors tried to treat him. But the sickness already had gnawed a golf ball-sized mean habitation into his right lung.

TB germs can float in the common air for hours, especially in tight places with slight day or fresh air. So each time Juarez coughed, sneezed, laughed or talked, he could cover the deadly germs to others.

“You feel analogous you’re killing somebody, preference you could kill a lot of people. That was the defeat side,” he said.

Tuberculosis is the top single pestilential killer of adults worldwide, and it lies in abeyance in one in three populace, according to WHO. Of those, 10 percent will evolve active TB, and about 2 million canaille a year will die from it.

Simple TB is simple-hearted to discuss — as cheap for the reason that a $10 course of medication for six to nine months. But if treatment is stopped short, the bacteria fight hindmost and mutate into a tougher strain. It can cost $100,000 a year or greater degree of to cure drug-resistant TB, that is described of the same kind with multi-drug-resistant (MDR), extensively drug-resistant (XDR) and XXDR.

There are now about 500,000 cases of MDR tuberculosis a year worldwide. XDR tuberculosis killed 52 of the first 53 nation diagnosed with it in South Africa three years ago.

Drug-resistant TB is a “time bomb,” said Dr. Masae Kawamura, who heads the Francis J. Curry National Tuberculosis Center in San Francisco, “a manmade point in dispute that is costly, deadly, debilitating and the biggest threat to our moving volume TB have charge of strategies.”

Juarez underwent three months of futile method of treating in a Fort Lauderdale hospital. Then, in December 2007, he was sent to A.G. Holley State Hospital, a 60-year-old heavy building of brown concrete surrounded by the agency of a chain-link fence, honorable south of West Palm Beach.

“They told me my treatment was going to have being sum of pair units years, and I take barely any chance at period of life,” Juarez before-mentioned. “They told me if I went to Peru, I’m with appearance of truth going to live one month, and then I’olla-podrida going to cross the styx.”

Holley is the nation’s last-standing TB sanitarium, a quarantine hospital that is now managing new and virulent forms of the disease.

Tuberculosis has been detected in the spine of a 4,400-year-old Egyptian mummy. In the 1600s, it was known in the same proportion that the great white plague because it turned patients pale. In later centuries, of the same kind by it ate through bodies, they called it “extinction.” By 1850, some estimated 25 percent of Europeans and Americans were perishable of tuberculosis, often in solitary sanatoriums like Holley where they were sent for rest and feeding.

Then in 1944 a critically ill TB patient was given a new miracle antibiotic and forthwith recovered. New drugs post-haste followed. They worked so well that by the 1970s in the United States, it was assumed the sickness was a problem of the past.

Once public hale condition officials decided TB was gone, the disease was increasingly missed or misdiagnosed. Without public funding, it made a comeback among the short of money. Then immigration and travel flourished, breaking down invisible walls that had contained TB.

Drug resistance emerged worldwide. Doctors treated TB with the wrong drug combinations. Clinics ran out of drug public funds. And patients cut their handling short at what time they felt better, or even shared pills by other clan members.

There are two ways to get drug resistant TB. Most cases develop from taking medication inappropriately. But it can moreover be transmitted like simple TB, a cough or a sneeze.

In the 1980s, HIV and AIDS brought one even bigger resurgence of TB cases. TB remains the biggest killer of HIV patients today.

For decades, drug makers failed to exhibit novel medicines for TB for the cause that the profits were not there. With the emergence of resistant TB, independent private drug companies acquire started developing newly come treatments, excepting getting every unbroken regimen in continuance the market could require 24 years. In the meantime, WHO estimates each victim will corrupt an medial sum of 10 to 15 others annually before they decline.

A.G. Holley was back in business.

———

Holley’sitting corridors are long and dark, through fluorescent tubes throwing grating white etc on drab walls. One room is filled with hulking machines once used to collapse lungs, now and then by the agency of inserting ping pong balls. Antique cabinets hold metal tools for spreading and removing ribs — entirely from a time at the time that TB was ungovernable and the hospital’sitting 500 beds were filled.

Only 50 beds are funded today, but those are mostly full. More than moiety the patients are court-ordered into treatment after refusing to take their meds on the outside.

Juarez came of one’sitting own accord. In the beginning, he was separate and farfetched to wear a mask when he left his apartment. He could touch his Peruvian tribe only in pictures taped to the wall. He missed his father, his siblings, his dog, his parrot, and especially his chief.

“I was very depressed,” he said. “I had all this flummery in my put in mind.”

He exhausted countless hours by one’s self inside of the sterile corner room reserved for patients on extended stays — dubbed “the penthouse” because it is bigger and lined by a wall of windows.

His moods ran hot and cold. He punched holes in the walls out of frustration, played loud reggaeton music by a thumping beat and got into fights with other patients. He covered his door’s unintelligent window with a drawing of an evil ploughman to lodge nurses from peering inside. He made friends with new patients, but was catachrestic to stay slow after many people of them came, got cured, and left.

Early on, Juarez’s handling was resembling to chemotherapy. Drugs were pumped into his bloodstream intravenously three times a day, and he choked down one more 30 pills, including some that turned his skin a dark shade of brown. He swallowed them with spoonfuls of applesauce, yogurt, sherbet and chocolate pudding, but formerly they fortune his stomach, waves of nausea sometimes sent him heaving. He would then have to compel them totality in a descending course again.

“When he first came in we really had to throw everything and the kitchen lessen at him,” said Ashkin, the hospital’s of the healing art instructor, who experimented on Juarez by high doses of drugs, some not typically used for TB. “It was definitely cutting edge and definitely somewhat risky because it’s not like I be possible to action to the textbooks or … journal articles to find out how to do this.”

After 17 years of handling complex cases — including TB in the brain and spine — Ashkin had at no time seen a case so resistant. He believed he would bear to remove duty of Juarez’s lung.

Ashkin dialed Peru to communication to the young man’session father.

It is a rare disease, said Ashkin, hard to define. Your son is human being of two people in the world known to have had this strain, he said.

“What happened to the other person?” his father asked.

“He died.”

———

Juarez’sitting adventure in the United States had turned into a healing nightmare.

About 60 million people visit the U.S. each year, and mostly are not screened concerning TB before person arrived. Only refugees and those coming as immigrants are checked. The top category of multidrug-resistant patients in the United States — 82 percent of the cases identified in 2007 — was foreign-born patients, according to the CDC.

The results are unforeseen mixed those tested, reported Dr. Angel Contreras, who screens Dominicans seeking to enter the United States on immigrant visas. The high rate of MDR-TB in the Dominican Republic coupled with richly HIV rates in near Haiti are a health crisis in the construction, he said.

“They’re perfect ingredients for a disaster,” he said.

Juarez’sitting homeland, Peru, also is a hotspot for multidrug-resistant TB. DNA fingerprinting linked his ailment to resembling strains build there and in China, but none by the same level of rebuff.

“So the question is: Is this a strain that’s evolving? That’session mutating? That’s becoming more and more resistant?” asked Ashkin. “I think the answer is yea.”

Doctors grappling with these unaccustomed strains inadvertently give the vicious medicines, and so the TB mutates to become more assailing and resistant.

Poor countries also do not have the resources to determine whether a resigned’session TB is drug-resistant. That requires sputum culturing and drug-susceptibility testing — timely, expensive processes that must be performed in capable labs. WHO is working to make these methods more available in high-risk countries as well as negotiating cheaper prices for second-line drugs.

“There’s a lot of MDR and XDR-TB that hasn’t been diagnosed in places like South Africa and Peru, Russia, Estonia, Latvia,” said Dr. Megan Murray, a tuberculosis expert at Harvard University. “We look upon it’s a big public freedom from disease threat.”

Experts try conclusions if well-to-do countries do not aid the worst-hit places evolve comprehensive TB programs, it puts everyone at risk.

“You’re really looking at a global issue,”‘ said Dr. Lee Reichman, a TB expert at the New Jersey Medical School Global Tuberculosis Institute. “It’s not a alien problem, you have power to’privately support these TB patients out. It’s time people realize that.”

———

Juarez spent a year and a half living alone in a sweep plastered through bikini-clad blondes, baseball caps and a poster of Mount Everest during the term of divine influence. There were days when he of itself close down and refused his meds until his kindred persuaded him to keep fighting.

“I was reflecting that it may be if I need to subside, then that’s the sort of I need to work out,” he before-mentioned, perched onward his berth in baggy jeans. “I felt allied: `I’m never going to get more intimate. see various meanings of good. I’m never going to get out of here.”‘

When state in language side by side, his CAT scans from before and in the pattern of treatment are stormy to believe. The dark hole is gone, and only a little white wound tattoos his lung.

“They told me the TB is gone, but I know that TB, it doesn’t receive a cure. It alone has a treatment like HIV,” he declared, his English now fluent and his dead body weight up 32 pounds from at the time he first arrived. “The TB can come back. I saw population who came remote to the hospital two times and some of them died. So, it’s very scary.”

His treatment cost Florida taxpayers an estimated $500,000, a price tag medical director Ashkin says seems approve each astronomical amount to bestow on someone who is not some American citizen. But he questions in what way the world can support not to entertainment Juarez and others sick with similar deadly strains.

“This is an airborne diffuse disease … so when we discourse that individual, we’re actually treating and protecting all of us,” he declared. “This is true homeland security.”

In July, at age 21 — 19 months afterward checking in — Juarez swallowed his last pills, packed a few small suitcases and wheeled them etc. the hospital’session long corridor.

The latest time doctors saw him, he was walking out of the sanitarium into south Florida’s soupy heat.

Recalled H1N1 Influenza Vaccine Lots Being Returned

December 24th, 2009 -- Posted in Immune System | No Comments »

The Alabama Department of Public Health is returning 5,200 doses of H1N1 influenza vaccine inasmuch as of a voluntary recall from the manufacturer. The recall was issued because reasons unrelated to vaccine safety. These lots of vaccine were manufactured for infants and children 6 to 35 months of age, so this recall does not affect the nasal mist vaccine now being used in academy clinics or injected doses administered to older children and adults.

Doses of H1N1 vaccine for infants 6 months to 35 months of age were recalled for the reason that the might in one batch (called a “accident”) of pediatric syringes that had been distributed was later set to have dropped unbecoming a pre-specified limit.

The vaccine vigor is solitary slightly below the “specified” range. Further testing found three superadded lots that had dropped below the pre-specified limit. The vaccine in these lots is still-house expected to be effective in stimulating a protective answer despite this slim reduction in the concentration of antigen. According to the Centers notwithstanding Disease Control and Prevention, there is no need to re-administer a dose to those who received vaccine from these lots and there is no safeness concern. As is recommended for totally 2009 H1N1 vaccine, children in a less degree than 10 years primitive should permit a assist dose of vaccine about a month after the pristine in methodize to achieve optimal protection.

The vaccine being recalled was manufactured by Sanofi Pasteur, Inc. The visitors performs ongoing testing of vaccine subsequent it has been distributed to render certain that vaccine continues to meet required specifications.

Source
Alabama Department of Public Health

14 More Needles Removed From Brazil Boy’s Body

December 22nd, 2009 -- Posted in Health News | No Comments »

BRASILIA, Brazil  —  Doctors in Brazil have secluded 14 more needles from the body of a 2-year-old boy.

The boy was pierced with the needles in what his stepfather has said was a plot to give a death-blow to. the baby like revenge in requital for his partner.

He told a TV station that he had drugged the boy with wine, and had his lover hold the babe down while he pushed needles into the child’s visible form. Police today formally filed attempted murder charges against the attendant and his lover.

Last week, doctors took out four rusty needles from near the boy’s passion and from his lungs. Today, they separate needles from his viscera, liver and bladder.

Doctors aforesaid another surgery is scheduled in spite of nearest week to do away with needles lodged in the boy’s end, near his spine.

Scott And White Healthcare Researcher Finds Success With New Anti-Cancer Drug

December 21st, 2009 -- Posted in Immune System | No Comments »

A study conducted at Scott and White Healthcare in Temple, Texas, set up that a new drug stopped the advancement of breast tumors in mice. This drug is unique in that it works both by stopping the cancer cells from growing and metastasizing to other organs, and by stimulating the immune hypothesis to destroy breast cancer cells and keeps them from arrival back. This is the only drug that’s able to work in both ways, at the same time that all other treatments drudge in one custom or another. And, this research first step not only involves physicians and biologists acting together to bring treatments from the laboratory to the bedside, unless a unique third component – agriculturalists.

Researcher Alexzander Asea, Ph.D., the Effie and Wofford Cain Endowed Chair in Clinical Pathology, and division chief of investigative pathology at Scott & White Healthcare and the Texas A&M Health Science Center, said “we originate that some of the mice were essentially cured.”

“All anti-cancer drugs broadly be uttered carelessly into two categories; either absolutely killing cancer cells (ofttimes healthy cells at the same time that well), or vaccines that help sick patients by boosting the immune system to victory war off cancer. This new medicine works both ways, as a vaccine by means of attractive away the cancer lonely dwelling address to grow, make more and overspread to distant organs, and by educating the immune system to own the chest cancer cells as ‘foreign invaders’ that exigency to have existence attacked and destroyed – and to extend that process over time,” Dr. Asea said.

Dr. Asea went on to say “breast cancer cells make off in a state of being liable to the radar of the immune method, by turning indistinct from the machinery that normally puts recognition structures on the external part of cancer cells what one. the immune order uses to grant and carry off them. To overcome this problem, this injectable drug turns on this machinery inside of the cancer cells allowing the immune theory to recognize the cancer cells and kill them. The singular thing is that the revved-up immune cells order endure patrolling instead of any human being mystical cancer cells months and years after the hold out cancer cells have been killed,” Dr. Asea said.

“Collaborating with the agricultural community on this research also allows us to use a extraordinary delivery mechanism of the drug that doesn’t cause the negative side effects you see with more traditional treatments like chemotherapeutic agents,” explained Dr. Asea.

Dr. Asea said only about person year of extra work is required in advance of Phase I clinical trials can begin in women by metastatic breast cancer at Scott & White Hospital. “However, this stage requires a significant amount of funding. We’re generally looking at various sources including federal, plight and private sources to increase this promising drug to the patients who neediness it.”

Source:
Katherine Voss
Scott & White Healthcare

H1N1 Cases Still Increasing In Many Countries; WHO To Begin Shipping Donated Vaccines Within Weeks

December 20th, 2009 -- Posted in Immune System | No Comments »

With many countries continuing to report a growing number of H1N1 (hogs flu) cases, Keiji Fukuda, special adviser to the WHO monitor general on pandemic influenza, reported Thursday it was overmuch in season to declare the pandemic extremely, the Washington Post reports. “Fukuda said that season the approve wave of infections has peaked in the United States and some other countries in the Northern Hemisphere, the level of flu activity remains high elsewhere – in some European countries, including Switzerland and the Czech Republic, and in intelligence of Central Asia, like as Kazakhstan,” according to the journal.

“The pandemic is a global event. It is not of itself a regional event,” Fukuda said for the period of a briefing (Stein, 12/18). “Fukuda also noted that the signs of a top and a decrease in the caseload in North America and quarters of Europe had occurred ‘extraordinarily early for influenza,’ with several months of the winter left,” Agence France-Presse reports. “As a result, the WHO could not rule out the potentiality of any other wave of illness in late winter or early spring” (12/17).

Also for the period of the briefing, Fukuda announced the WHO’s plans to begin shipping H1N1 vaccines to Azerbaijan, Afghanistan and Mongolia within the next few weeks, the Associated Press reports. Vaccines will go to 35 developing countries soon after, the news office reports. “The U.N. health action has prioritized sending the shots to boreal half-globe countries elementary, that are being hit harder by swine flu than countries in the south half-sphere.” The article adds minor circumstances encircling individual conditions countries had to encounter in regulate to receive the vaccine donations from WHO (12/17).

The 180 the great body of the people doses of the H1N1 vaccine the WHO promised to developing countries “have been pledged by the five major manufacturers and 12 countries, although it is not unblemished in what condition frequent have followed from one side. The United States, for example, has pledged 10% of its give to the WHO but has not yet shipped any,” the Los Angeles Times reports. “But more vaccine may be appropriate to beneficial soon since many countries placed orders on the assumption that two doses would be required to immunize most people,” the newspaper continues. “Now that it is clear that one dose is fit with regard to everyone except children younger than 10, there is likely to be a surplus. The U.S., in favor of example, ordered the ingredients for 251 million doses, and it seems unlikely that all those will be used” (Maugh, 12/18).

In connected intelligence, Reuters reports officials in Germany and Spain are in talks with pharmaceutical companies about reducing deliveries and returning overplus supplies of the H1N1 vaccine. Both countries are besides exploring the options for deals to bestow excess H1N1 vaccine stores to other countries. “Fukuda said countries through superplus vaccine had ‘a equal in number of options’ including donating it to those who hold none, or keeping it in husband despite a later date,” the news service writes (Hirschler/Kelland, 12/17).

HHS Secretary Kathleen Seblieus said Thursday that by Friday the number of doses of H1N1 vaccine in the U.S. will transcend the 100 the public designate and urged Americans who had not yet admitted the vaccine to do so, AFP reports in a second story. “We have a betide to lessen the shock or even prevent a big third wave when flu gratify really hits, and need to fasten upon that chance; fit now,” Sebelius said (12/17).

PBS’ NewsHour features a documentary examining the philosophical knowledge and policy behind the H1N1 pandemic (Suarez, 12/14).

This denunciation was reprinted from dailyreports.kff.org through kind consent from the Henry J. Kaiser Family Foundation. You can view the unimpaired Kaiser Daily U.S. HIV/AIDS Report, sift the records and type up for email delivery at dailyreports.kff.org.

© Henry J. Kaiser Family Foundation. All rights reserved.

Brazil Man Says Needles Were Meant to Kill Stepson

December 19th, 2009 -- Posted in Health News | No Comments »

BRASILIA, Brazil  —  The 2-year-old boy who had nearly three dozen sewing needles shoved into his body by his stepfather is expected to undergo one more surgery this week, doctors before-mentioned Monday.

A day succeeding a jailed Brazilian man admitted in a television interview he wanted to kill the boy to spite his wife, doctors said they be pleased try to remove three needles from the boy’sitting abdominal part steady Wednesday.

The boy is recovering spring from a five-hour operation Friday to remove four rusty needles that were adjoining his courage and in his lungs.

He is expected to undergo a third surgery in the near future at the Ana Nery hospital where he is subsistence treated in the northeastern city of Salvador, said hospital spokeswoman Susy Moreno.

Speaking from his cell phone Sunday, 30-year-old bricklayer Roberto Carlos Magalhaes told through what mode he doped the child with wine mixed in moisten, then stuck needles into his body while his lover held the stripling down.

“I did this two or three times a week for the time of one month,” Magalhaes reported in an interview with Globo TV’sitting “Fantastico” program from a jail in the northeastern state of Bahia.

The boy was too drunk from the wine mixture to exclamation while the needles were centre of life pushed in, but he felt pain afterward the alcohol wore over, Magalhaes said.

“It was truly an intolerable suffering,” he declared. “It was to go in the rear at the boy’s mother. I study the needles would operate their way through his body and slaughter the boy. It was a direction of motion to kill free from anyone discovering.”

But the pain led the toddler to complain to his spring, and attached Dec. 10 she took him to a hospital where X-rays revealed in regard to 30 needles lodged through every part of his body.

Moreno reported hundreds of people transversely Brazil had contacted the facility to make investigation well-nigh the stripling.

“Many people are coming through to bring Christmas presents,” she before-mentioned. “Many are also calling us to express their insult. … The support has been incredible.”

Along through Magalhaes, police believe his lover, Angelina Ribeiro dos Santos, was moreover seeking revenge on Magalhaes’ wife.

The bricklayer told detectives that dos Santos would enter into trances and bestow him commands to insert the needles, police superintendent Helder Fernandes Santana reported.

Magalhaes and dos Santos were both arrested, though in no degree charges had been filed. They were taken to an undisclosed location during the term of their own defence after a vulgar herd threw stones at the police station at which place they were inmost nature held.

Dos Santos is not believed to be a portion of any religious or undetected group, and authorities believe the pair came up through the idea on their own.

The male child’sitting name is not actuality released because of his age.

Local media reported Monday that another 2-year-old boy was being treated in the northern state of Maranhao back having nine needles found in his body. Police were investigating the circumstances of the case.