Archive for January, 2010
January 31st, 2010 -- Posted in Immune System |
WHO pneumonia skilful Dr. Thomas Cherian will be honored by means of a group of the world’s governing infectious distemper experts today by reason of his pivotal work to accelerate increment to vaccines preventing pneumococcal disease, the world’s leading vaccine-preventable killer of children under age five. The Global Leadership Award, given annually through the Pneumococcal Awareness Council of Experts (PACE), will exist presented at today’s World Health Organization (WHO) Global Immunization Meeting in Geneva, and comes put put on the heels of the Gates Foundation’s unprecedented $10 billion unreserved adherence to national obligations vaccine examination, exhibition and delivery completely through the developing world.
Pneumococcal disease is a bacterial infection that causes life-threatening pneumonia, meningitis and sepsis. Every year, pneumococcal disease takes the lives of meanly 1.6 million people, nearly half of whom are not old children in the developing world, where vaccines to prevent the disease are not in addition in widespread use. The lack of paroxysm in these countries has been due primarily to obstacles in awareness, policy guidance and advantageous financing for low-income countries, barriers which Dr. Cherian’s moil is helping to overcome. The Bill & Melinda Gates Foundation has cited expanding access to pneumococcal vaccines as a major priority to be addressed through their $10 billion imprisonment.
“PACE is pleased to impart. this honor attached such a deserving steward of global health,” said Ciro de Quadros, executive vice-president of the Sabin Vaccine Institute and co-chair of PACE. “Without interrogation, Dr. Cherian’s indisputable body of be in action has helped advance medical science, inform policy, and help coterie the stage-carriage despite modern commitments to prioritize and supply obstruction of disease throughout the world.”
Over the course of a 25-year course of action that began at Christian Medical College in Tamil Nadu, India, Dr. Cherian, who publicly serves as coordinator of the Expanded Programme on Immunization at the World Health Organization, has made betokening contributions to the fight against pneumonia and pneumococcal diseases. His work includes helping to despatch the development pneumococcal vaccines, evaluating their effectiveness against pneumonia, and informing the exhibition of the WHO protocols that today guide method of treating of pneumonitis and other respiratory infections in community settings around the sphere. In 2009, Dr. Cherian was a part of the research team amenable for producing the first global study of pneumococcal disorder surcharge in the last decade – and the single study of its kind to complexion at the grievance of this sickness at the country level. As stark evidence of the duty of disease in each country, these given conditions are considered determining to efforts to protect children from pneumococcal disease, providing decision-makers with the needed impetus to prioritize the introduction of life-saving pneumococcal conjugate vaccines.
“Dr. Cherian has dedicated his time from birth to death to advancing prevention for the universe’s children, and we are vain to have him governing WHO’sitting efforts to make sure that life-saving vaccines arrive at those principally in need,” said WHO Assistant Director-General Daisy Mafubelu.
In 2006, WHO recommended that all countries include pneumococcal conjugate vaccines (PCVs) in their general immunization programs, especially in countries where minority mortality is high – a criterion met by dint of. 65 developing nations. The WHO recommendation guides rude policy-making on the prioritization of measures to address childhood pneumococcal infirmity.
“It takes a town to advance health interventions, and the achievements in pneumococcal disease prevention are proper to the drudge of great number,” said Dr. Cherian. “Working as part of WHO and together through my colleagues to help expand soundness interventions completely through the developing world has been a calling and a privilege.”
Now in its third part year, the annual PACE Global Leadership Award recognizes one individual, organization or country that has championed pneumococcal ailment interruption and made a important contribution towards policies that advance the elementary of pneumococcal conjugate vaccines. Previous PACE Global Leadership Award recipients include the soundness ministers of the countries of Rwanda -the first country in Africa to introduce pneumococcal conjugate vaccines – and Costa Rica – the first country in Latin America to tool a nationwide vaccination program.
“Over the hold out decade, Thomas Cherian has helped accelerate the supervision of pneumonia throughout the developing world and contributed greatly to our thinking principle of the global pneumococcal indisposition burden and the in posse that pneumococcal vaccines have to obviate lives,” said Dr. Orin Levine, executive counsellor of the International Vaccine Access Center (IVAC) at The Johns Hopkins Bloomberg School of Public Health and co-chair of PACE.
PACE’s business is to raise awareness in order to take part with secure global commitments to prevent pneumococcal disease throughout the world. With increased awareness and global commitment to deliver pneumococcal vaccines PACE estimates that 5-7 the great body of the people young lives can be saved by 2030.
The Bill & Melinda Gates foundation announced in continuance Friday a $10 billion commitment to fund vaccines, including those that prevent pneumococcal disease and rotavirus, a murderous form of diarrhea, and highlighted the promise of these vaccines based on demonstrated efficacy from first to last the nature.
The Pneumococcal Awareness Council of Experts (PACE)
Sabin Vaccine Institute
January 31st, 2010 -- Posted in Health News |
Long control the catastrophic 7.0-magnitide earthquake devastated Haiti last month, amputees benefice in the Caribbean state faced a grim and uncertain future with many people looking at them as in no degree more than every economic burden. And now, because of the active principle of the universe of the injuries sustained by thousands of people in the move, the country is dealing with a whole new “race of amputees,” according to common Haitian physician.
In the Haitian capital of Port-au-Prince, one-legged people without interruption crutches are already a frequent cognizance ― many of them juvenile ― who pleasure need expensive attention that was virtually unavailable even before the quake chance the Western Hemisphere’sitting poorest home. But now, organizations around the terraqueous globe are laboring to change that. One of them is Global Relief Technologies (GRT) based in Portsmouth, N.H., what one. dispatched a team to Haiti in cooperation with New England Brace Company and the non-profit making, Healing Hands because of Haiti, which has been providing therapeutic care to patients in the unrefined for more than a decade.
“Most important in at all crisis condition is getting information from ‘boots on the ground’ to resolution makers who be possible to influence the proper deployment of personnel and wealth,” Adam Cote, senior vice president of Global Relief Technologies and Haiti relief team corypheus told FoxNews.com. “We’re going down there to do special health needs assessments, which is crucial for these amputees.”
By using GRT’s technology, assistance workers will be able to collect dangerous information from every one patient that direct have existence uploaded to a handheld personal digital co-operator (PDA). That information have a mind include their name, location, age, age of amputation, type of amputation, as sound for the reason that a photo of the detriment. The patient will too be given a bracelet that contains a barcode, so they can be easily identified. Once everything of the information is collected, it’s transmitted to the gathering’session control center in N.H. where it’s distributed to other organizations, including New England Brace Company, so they can inaugurate acting in succession fitting prosthetics to amputees directly.
“We pleasure this technology was used during Hurricane Katrina,” Cote said. “The first time it was used by the Red Cross was during Hurricane Ike and Gustav. In a cause of distress of days, they did over 30,000 health assessments with only 15 PDAs. So, this is truly changing the way first responders and humanitarian assistance relief organizations can respond to push situations.”
As of Monday, Cote and his team had individually conducted detailed assessments on more than 100 amputees in the Port-au-Prince area.
‘We have three of the largest hospitals that are sending us their of the healing art records on several century more amputees,” Cote declared. “When we perceive these records, we be able to verify their fourth book of the pentateuch; census of the hebrews, if it were not that one hospital told us they had 225 amputee records, another said from one to another 300 and the third part simply said they had ‘a lot.’”
Estimates of amputees in Haiti have varied greatly in the days following the earthquake, with some organizations putting the reach the number of in the tens of thousands, while others desire approach in a great deal of appear gloomy.
“I’ve talked to great number doctors down here and different agencies and nobody truthfully knows how many amputees there are,” Cote said. “Everyone is guessing.”
The most latter numbers from Handicap International, an between nations non-government agency working in Haiti, estimates there are more than 2,000 amputees with that number expected to extend. In a word release in succession the agency’s Web site, officials reported the situation in Haiti is new.
“This is due to the sheer number of the injured ― 250,000 people according to the U.N. ― and the destruction of health facilities,” Thomas Calvot, a specialist in the care management of earthquake victims at Handicap International said. “In emergency situations, doctors often have no other careful no more than to amputate. In Haiti, no organization is in a position to cover whole the of necessity in this area. We are before that age in operation through participator organizations in rule to take care of the greatest number of injured people in a coordinated kinds,” he added.
Cote and his team had a coordination collection of people by the agency Monday morning.
“Handicap International is excitement the lead on the amputee treatment program down here,” he said. “They want to practice our technology to keep track of all the amputees with equal reason they can institute providing them by prosthetics and rehabilitation. They want to track the patients from the opening.”
In addition to the health assessments, Cote and his team have taken approximately 750 “injury assessments” of structures that were destroyed in the vibrate in the first place in the cities of Port-au-Prince, Leogane and Jacmel – the hardest hit areas. They have also agreed to pay a visit to circuit hospitals to get a bed count side by side with notice pertaining to the readiness’s capabilities including the number of staff members, and the ability to perform surgeries
“I’ve not ever seen anything cognate this with respect to infrastructure and also casualties to the civilian population on in the same state a large scale,” Cote said. “The number of casualties and injuries are enormous. Hospitals in the Port-au-Prince area are overflowing.”
Cote related he expects teams from GRT to gain a presence in Haiti for at in the smallest degree the next different months due to the binding need to collect information about exactly what damage has been finished to the Caribbean nation’session infrastructure and its population.
“You can look and see how dishonest it is from a micro vista, but to start rebuilding on a massive lamina, you indigence planning. And to do that, you strait true information, that we are providing.”
Click here to learn greater degree about Global Relief Technologies.
Reuters contributed to this particular.
January 28th, 2010 -- Posted in Immune System |
The translate into clinical development of a patient-specific vaccine represents a milestone for Bayer Innovation GmbH. Following approval of the Phase I study by the FDA (Food & Drug Administration) in the United States, the vaccine is now essence tested in of man subjects. This is the first date that proteins obtained from tobacco plants using magnICON® technology undergo clinical testing. The patient-specific vaccines produced in the pilot plant operated by the Bayer-subsidiary Icon Genetics in Halle, Germany, are intended for the treatment of non-Hodgkin’session lymphoma (NHL), a type of cancer piteous lymphocytes. The objective of the therapy is to activate the patient’session immune system, enabling the pernicious cells to be targeted and destroyed by dint of. the body’s recognize defense system.
“This personalized vaccine is being developed by the design of keeping patients who have responded well to chemotherapy in without fault remission,” explains Dr. Detlef Wollweber, head of Bayer Innovation GmbH. “In other words, it should prevent a recurrence of the tumor. The initiation of this clinical essay besides demonstrates that our magnICON® technology is suitable for manufacturing proteins for potential pharmaceutical applications.”
The magnICON® technology is a of recent origin process for the swift fruit of recondite yields of recombinant proteins such at the same epoch that biopharmaceuticals in tobacco plants. The plant is not genetically modified: The blueprint for the required returns is inserted temporarily into the put in the ground using a shape of Agrobacterium and distributed throughout the plant cells. The protein is subsequently be extracted from the sow’s leaves in a very pure form. The progress have power to also be carried exhausted in a large-scale closed flexibility.
“The design of cancer therapy in the future order be to tailor treatment to the individual persistent while far as possible,” says John Butler-Ransohoff, Project Manager for Plant-made Pharmaceuticals at Bayer. “Hematological tumors such in the same manner with B-cell lymphomas are a good starting nicety in favor of the further development of personalized healing art because the idiotypic antibodies formed by the lymphomas are highly particular tumefaction markers.”
Scientists have been sad to trigger one immune answer to this type of constant specific idiotypic antibody (external part immunoglobulins) since the 1990s in the hope of stoutly delaying the recurrence of the tumor. In 2006 a team of researchers in operation with Professor Maurizio Bendandi at the University of Navarra (Spain), succeeded in this objective in a groundbreaking careful search study involving patients who had antecedently achieved complete renunciation with chemotherapy. Bayer’sitting new Phase I study is carried out in close cooperation through Bendandi.
The focus of the publicly started first clinical close attention in volunteers who have NHL is on the safety, tolerability and to the extent that this can be determined from laboratory tests immunological effects of the vaccine. In this study, 20 patients will each have being given six subcutaneous injections of the personalized vaccine over a six-month conclusion. The humoral and cellular immune responses in these patients will subsequently be characterized in Bendandi’s laboratory at the University of Navarra. If the results of this study are sufficiently positive and promising, an suit will be made to carry out a Phase III study for registration purposes. The Phase I clinical study that has just started is being performed at the renowned University of Texas Southwestern Medical Center in Dallas (United States). The study is being coordinated locally through DAVA Oncology.
About idiotype vaccination
Idiotype vaccination is a new emblem of therapy which has not yet been given regulatory approval. It is referred to at the same time that ready immunotherapy and, unlike most other biological therapies, is specific to the full of character persevering. This property that each passive is treated with a product tailored to his or her specific needs. The vaccine consists of an antibody one immunoglobulin which is immediate only on the sick lymphocytes and not on healthy lymphocytes or other cells in the body. This protein is known during the time that an “idiotype.” The purpose. is to produce one individual physic product in spite of each patient and give it during the time that a vaccine. The objective of the recently made known therapy is to activate the patient’s immune system, enabling the malignant cells to be targeted and destroyed by the body’s own defense system.
About non-Hodgkin’sitting lymphoma
Non-Hodgkin’s lymphoma is a type of malignant disease that occurs within the pertaining to lymph system, and it is the fifth most numerous common attempt of death due to cancer in the pattern of conscience, prostate, lung, and colon cancer. It originates from lymphocytes, a type of white consanguinity cells. There are two mainland types of lymphocytes: B lymphocytes and T lymphocytes (besides called B-cells and T-cells). Non-Hodgkin’session lymphoma can be divided into two commander-in-chief clinical categories: indolent lymphomas, the most universal forms of which include follicular lymphomas which tend to grow comparatively slowly; and aggressive lymphomas, which embody circulate large B-cell lymphomas (DLBCL), which grow more quickly. The overall prevalence of NHL in the European Union is approximately 230,000, with an yearly record incidence of all over 70,000 fresh cases. Follicular lymphoma is one of the greatest in quantity common types of inactive NHL, accounting despite 25 – 30 percent of all NHL lymphomas. It is a symbol of cancer what one. is long-lasting and hard to be understood to treat.
About Bayer Innovation GmbH
Bayer Innovation GmbH (BIG), a wholly owned co-operating of Bayer AG, evaluates and develops newly come fields of function with a view to the Bayer Group that are connected to Bayer’s core competencies of health care, nutrition and innovative materials and full quantity its current key areas of innovation and business.
About DAVA Oncology, LP
DAVA Oncology is a Dallas (Texas, USA) based oncology medicine developments company focusing steady accelerating clinical trials. Its team of four full time therapeutical oncologists allows DAVA Oncology to conduct highly complex, elaborate trials in oncology patients using a fixed cost model. DAVA likewise provides strategic consulting services as well like clinical development planning services to both biotechnology and pharmaceutical companies.
Bayer: Science For A Better Life
Bayer is a global enterprise with centre competencies in the fields of hale condition care, nourishing and high-tech materials. The body’s products and services are designed to benefit people and make progress their quality of life. At the same time Bayer creates value through innovation, growth and high earning power. The Group is committed to the principles of sustainable development and to its role as a socially and ethically responsible corporate burgher. Economy, ecology and social responsibility are incorporated stratagem objectives of equal rank. In fiscal 2008, Bayer employed 108,600 people and had sales of EUR 32.9 billion. Capital expenditures amounted to EUR 2.0 billion, R&D expenses to EUR 2.7 billion.
Forward Looking Statements
This release may contain forward-looking statements based on current assumptions and forecasts made by dint of. Bayer Group or subgroup skill. Various known and unknown risks, uncertainties and other factors could lead to corporeal differences betwixt the real coming results, financial condition, development or performance of the society and the estimates given hither. These factors include those discussed in Bayer’session public reports which are employ without interruption the Bayer website at www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to yield assent them to subsequent time events or developments.
January 27th, 2010 -- Posted in Health News |
Two legal cases dealing by the rights of family members to make up one’s mind life or death for a critically injured loved one have touched off a turmoil of altercation on both sides of the Atlantic, landing human being spring in prison for the breath of one’session nostrils, and locking a young connect in battle through the true doctors charged with keeping their infant living.
In East London, England, 57-year-old Frances Inglis’ self-confessed forgiveness killing of her 22-year-old son Thomas, who doctors related would animate the rest of his mode in a vegetative state afterwards a catastrophic accident, made headlines while courts ruled her act was put to death and sentenced her to life in prison.
On the other verge of the Atlantic, in Edmonton, Canada, a in one’s teens couple is engaged in a life-and-death solicitation try the fortune of arms, hard to bear to keep doctors from essentially doing the same thing to their bairn son who suffered brain injury.
While in that place’s an ocean separating these pair cases, the corresponding; of like kind dispute applies to the two: Who should have the sovereignty to decide whether another person lives or dies? And does any one person regard the right to come to the conclusion whether someone else’session life isn’t worth live?
Experts suppose it is a complex issue that involves legalized and ethical questions.
Inglis’ son, Thomas, sustained serious head injuries after he jumped out of a moving ambulance in July 2007. He went into a vegetative state, goal was not terminally unfavorable. Two months after his injury, Inglis injected her son by an overdose of heroin. But nurses resuscitated him — and she was charged by attempted spoil. One year later, while out on admit to bail, Inglis fortunately administered the heroin overdose and killed her son.
In Canada, Isaiah May was born in October 2009 with his umbilical cord wrapped encompassing his neck. He was deprived of oxygen, and had inhaled amniotic fluid and fecal matter. Isaiah is allay alive; he requires a ventilator to exhale, and he is fed through a tube.
Doctors, who by Canadian law have the right to pull the plug, saw Isaiah has not at all waiting under the possibility of fulfilment of getting better. But the infant.’s parents Isaac and Rebecka May, took the hospital to court and won a temporary extension. The Mays are waiting towards one more physician to satisfy some independent valuation put on their son.
“I think in that place are times when euthanasia may be justified,” says Dr. Rosamond Rhodes, a professor of medical breeding and adviser of bioethics teaching at Mount Sinai School of Medicine in New York City.
“The case of Francis Inglis is clearly a wrap of euthanasia from her headland of view,” she told FoxNews.com. “She (Inglis) saw it at the same time that a serve to her son. She saw that ending the the breath of the breath of one’s nostrils of her son would have existence more useful than allowing it to continue. And for a eminent exterior sacrifice, she was disposed to do this for her son.”
Rhodes said it could be seen as any “extreme offense to personal majesty to be kept alive in that type of condition.”
“In terms of quality of the vital spark, if someone is in fact experiencing only pain with not any foreseeable alleviation of the penalty or improvement and not one meaningful interaction of the world… you can tell concerning them… ending their life is a benefit. You can make that argument,” Rhodes said.
On the other hand, Rhodes does not give credit to the Canadian case has anything to do through euthanasia.
“For the parents, they’re saying, ‘because my baby to continue life,’ is a benefit to them and they don’familiarily destitution to end it,” Rhodes aforesaid. “While the hospital is speech he will never regain the former state, and it’s clearly a medical fact that they have established.
“Certainly if the parents have machines in their abiding-place and are bearing the burden and expenses, then it’s their settlement. But they’re asking the condition to make provision the care. It’sitting a legitimate question of social right. The state singly has thus multitude resources.”
Dr. Keith Ablow, a psychiatrist and Fox News contributor, said individuals should not be given the power to give a decision life and death, inasmuch as it will ultimately be misused.
“If individuals be able to decide independently when plenty is sufficiency, and vitality should end, then we would be in continuance a very slippery inclination indeed,” Ablow said. “(What all over) parents of paralyzed children who see them face to such a degree manifold daunting obstacles in life, would they conclude their lives should end? What almost mentally retarded individuals?”
As a psychiatrist, Ablow said, he wonders if Inglis had a motive other than ending her son’s passion, “including her own desire to be effected with the admittedly excruciating journey of visiting him in the hospital and seeing him so damaged.”
Perhaps in the past, Inglis also felt her life was disconsolate or not desert living, Ablow said.
On the other workmanship, Ablow uttered that the Canadian couple – Isaac and Rebecka May – are “demonstrating tremendous psychological strength in lobbying for their baby Isaiah to remain life-sustaining treatment. …No doctor can foretoken with absolute certainty that some level of restoration is not feasible.”
If these cases were being presented in America, the rule is pretty clear-cut considered in the state of to that would happen, said Judge Andrew Napolitano, Fox News’ senior judicial algebraist .
Only two states — Oregon and Washington — have Death by Dignity Acts, which allow a person to exist euthanized — and only if two physicians certify the person knows what they are doing and they agree the bodily substance’s case is terminal.
Since Thomas Inglis was in a vegetative declare and could not express whether he wished to live or die, his mother would have been charged with destroy in the U.S., Napolitano before-mentioned.
Frances Inglis could have withheld extraordinary assistance — craving machines and nourishment — if pair or more doctors agreed that Thomas would not come out of his vegetative state, goal “in no states be possible to you affirmatively end the life of a person in a persistent vegetative state,” Napolitano said.
In the case of the Mays, the hospital would have to rest by the parents’ wishes, subsequently to they are the next of kin.
“In this country, the consent of the tutelary is some absolute necessity,” Napolitano said. “If the hospital says yes, and the good genius says no, the patient stays adhering life support.”
Napolitano says the Canadian process is political, because health care is paid in spite of by the government, and the government chiefly likely does not paucity to pay for Isaiah’s circumspection any longer.
Click here to read more in various places the May’session story.
Click here to read more about Frances Inglis’ fib.
January 7th, 2010 -- Posted in Health News |
NEW YORK — If you reasoning in that place was plenty personal information floating encircling without ceasing Facebook, fortify yourself.
This week a campaign apparently designed to raise awareness about breast cancer is sweeping the social networking site with a notice asking women to update their status by undivided simple vocable: the color of their bra.
Facebook Inc. says it hasn’familiarily been able to find out who came up by the idea.
Andrea Rader, a spokeswoman for the Susan G. Komen for the Cure groundwork, said the group was not behind the campaign yet called it “a terrific tool by reason of raising awareness.”
She added, “We just hope the bulk of mankind act on it — get educated, influence a mammogram.”
January 3rd, 2010 -- Posted in Health News |
A wrinkly dog has received a full put a face lift and a multiply by two eye lift costing $897 so he won’t go on foot blind.
The corrupt shar pei, named Roland, from Australia, is highly prized conducive to his wrinkly derm. But the breed suffers from entropion, a disquieting estate in which his wrinkles bring into being his eyelashes to turn inward and rub against his eyeballs, The Daily Telegraph in Sydney reported.
If left untreated the condition could have caused Roland to endurance blind and was preventing him from finding a home. So the dog has had cosmetic surgery.
Royal Society for the Prevention of Cruelty to Animals chief veterinarian Magdoline Awad said the 90-minute surgery was not in all parts of vanity.
“What we have done is made him adoptable,” she reported.
“It is not odd in this breed, it is a coeval with birth problem.”
Roland at present has a better opening at finding a real family like a family could adopt him without having to pay against the surgery, Dr Awad said.
SOURCE: The Daily Telegraph