Allegheny General Hospital Study Demonstrates Safety And Potential Efficacy Of Oral Allergy Treatment

An oral allergy treatment administered in drops under the dialect is a sure and effective other to injections despite adults who are allergic to ragweed pollen, according to a study published in the Journal of Allergy and Clinical Immunology by allergic disease specialist at Allegheny General Hospital.

Widely used in Europe, but not yet approved by the U.S. Food and Drug Administration, sublingual allergen immunotherapy (SLIT) can be a more beneficial and tolerable method of treating approach that leads to greater patient compliance, said David Skoner, MD, instructor of AGH’session Division of Allergy, Asthma and Immunology and a co-lead conductor of researches in the examine.

“The study’s tools and materials mark a step front in gaining approval for sublingual president and cabinet of allergy medication,” said Dr. Skoner, “We believe a spacious number of patients would greatly benefit from having access to this of the present day verbal treatment to ease their symptoms.”

“The sublingual method so far has been safe, and the adherence rate should be more valuable because no injections are involved and the medication is administered at domestic,” said co-investigator Deborah Gentile, MD, Director of Research in AGH’s Division of Allergy, Asthma and Immunology.

The AGH study, “Sublingual Immunotherapy in Patients with Allergic Rhinoconjunctivitis Caused by Ragweed Pollen,” involved 115 patients in Pittsburgh, Madison, Wisc., Iowa City and Evansville, Ind. They were randomly assigned to a medium or high drench of standardized glycerinated short ragweed pollen pull out or to a placebo. Participants kept diaries to monitor their symptoms in addition the conduct of 17 weeks for the period of the ragweed pollen accustom.

The frequency of daily symptoms, as well at the same time that the penury for adscititious medication to discuss symptoms, both dropped significantly as being those catching the high-dose medication, versus those taking a placebo. The frequency of unfavorable events was like betwixt the placebo and treatment groups.

The researchers concluded that SLIT was safe and can reduce symptoms in ragweed-sensitive patients, though greater amount of trials are needed to definitively establish the process’s efficacy.

Shortcomings of previous trials through the sublingual method included small patient populations, high withdrawals and brittle method of treating duration. Questions remaining in continuance SLIT include manipulation schedules, optimal doses and cost-effectiveness.

Other researchers involved in the study were Robert Bush, MD of the University of Wisconsin School of Medicine and Public Health; Mary Beth Fasano, MD, University of Iowa Hospitals and Clinics; Anne McLaughlin, MD, of Wellborn Clinical Research Center in Evansville, Ind., and Robert E. Esch, PhD, of Greer Laboratories Inc., Lenoir, NC.

Source: Allegheny General Hospital

February 12 2010 07:24 pm | Immune System

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