Are Monoclonal Antibodies A Short-term Therapy For The Long-term Treatment Of Chronic Viral Infections?

Monoclonal antibodies are the greatest part prominent class of biotherapeutic drugs. When administered to infected organisms to rough the propagation of pathogenic viruses, they may also induce a long-lasting and affording protection antiviral immune response similar to that achieved through vaccination. These results obtained in mice by the “Oncogen?se et Immunoth?rapie” group at the Institut de G?n?tique Mol?culaire de Montpellier (CNRS/Universit?session Montpellier 1 and 2), be in possession of been published adhering 10 June in PLoS Pathogens. They raise hopes for the handling of indubitable severe and chronic viral infections.

Antibodies (AB) are molecules that are produced by the immune system to defend itself against cancer cells and infective agents. Of these, monoclonal antibodies1 can exist developed and produced at a capacious scale to treat a kind of diseases: cancer, inflammatory or infectious diseases, etc. They thus constitute the largest class of biotherapeutic drugs to age and are being considered with increasing interest on account of the manipulation of acute and chronic viral infections such as HIV (Human Immunodeficiency Virus) or HCV (Hepatitis C Virus), against which current therapies are still unfitted.

Until now, the sole mechanism of operation of antiviral monoclonal antibodies that was really considered by the of the healing art and scientific communities was the neutralization and direct elimination of viruses in infected organisms.

Using a standard of viral leukemia in mice, the “Oncogen?se et Immunoth?rapie” collection at the Institut de G?n?tique Mol?culaire in Montpellier (CNRS/Universit?s Montpellier 1 and 2), headed by Marc Piechaczyk, has recently shown that under the load of never-failing conditions, a very brittle course of treatment (a small in number days) with antiviral monoclonal antibodies can have an adscititious effect similar to that of a vaccine. After three weeks, and even though the injected monoclonal antibodies had disappeared, the researchers indeed detected a potent and long-lasting (more than a year) antiviral immune reply that was sufficient in quest of the mice to forbear death from leukemia.

The team identified an unexpected mechanism enabling the monoclonal antibodies to induce protective antiviral immunity. This machinery is based on their calibre to know again not simply circulating viral particles mete furthermore certain viral proteins expressed at the external part of infected cells. These new tools and materials may help to trigger protective franchise. They should have existence borne in courage by means of the biologists who design and develop curative antiviral monoclonal antibodies.

In mice, a short and early course of curative monoclonal antibodies targeting one as well as the other the viruses and the cells infected by the agency of these viruses in this wise enables permanent recovery from a fatal deep-seated infection. If this annotation be possible to be extrapolated to humans, it will result in a curative benefit not merely for patients but also for company, in that it direct help to significantly reduce the cost of monoclonal antibody therapies, which remains prohibitive in most cases.

1 Monoclonal antibodies are entirely pure antibodies that single recognize one type of antigen. Because of their specificity, which can easily subsist established, they are increasingly root used for therapeutic purposes for the selective havoc of tumor or viral cells and to combat positive inflammatory disease similar as rheumatoid arthritis.

Source: PLoS Pathogens

June 12 2010 02:32 pm | Immune System

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